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To shrink the prostate and the tumor before a procedure, in order to reduce the likelihood of escape ( neoadjuvant therapy).

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Some men continue to choose this option, however, because it remains the most efficient way to reduce testosterone levels, and it eliminates expenditures on medications and multiple visits for monitoring side effects that would be needed to achieve the same results.

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Multiple agents are now reported to improve survival for patients with metastatic prostate cancer that has progressed after androgen-deprivation therapy.

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Unfortunately some men have them for as long as they stay on treatment.

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GnRH analogue, while certain other side effects, including hot flashes, depression, fatigue, and sexual dysfunction, occur much more frequently in combination with a GnRH analogue.

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Healthcare staff should be trained to recognize that it takes more effort to make men feel comfortable, and office hour schedules should accommodate working men.

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As such, although bicalutamide has not been compared head-to-head to CPA or spironolactone in the treatment of androgen-dependent conditions, flutamide has been found to be either equivalent or more effective than them in clinical studies, and the same would consequently be expected of bicalutamide.

Taking bicalutamide in combination with a GnRH agonist can increase the risk of high blood sugar or developing diabetes.

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Lack of oxygen makes the central cells more resistant to radiotherapy.

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Following the first analysis of the full EPC programme data set, the study blind was broken due to a significantly lower risk of objective disease progression with the addition of bicalutamide to standard care compared with placebo.

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Base the decision to perform a biopsy on PSA testing and DRE.

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However, if bicalutamide is given to a woman, conceiving a child (getting pregnant) should be avoided.

Lymphoedema can cause discomfort, pain and difficulty moving.

In clinical trials with Bicalutamide Tablets, USP 150 mg as a single agent for prostate cancer, gynecomastia and breast pain have been reported in up to 38% and 39% of patients, respectively.

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CASODEX 150 mg daily is not approved for use as therapy for patients with localized prostate cancer who are candidates for watchful waiting.

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After the cancer has become unresponsive to androgen-deprivation therapy, prostate cancer will usually have produced metastases.

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Management of gynecomastia should include evaluation, including laboratory testing, to identify underlying etiologies.

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It is more accurate than PSA testing alone and improves its usefulness by increasing the ability to pick out high-risk prostate tumors from low-risk tumors, which can help to avoid unnecessary biopsies (PCF, 2013a; Tomlins et al.

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Patients with this disorder have an increased risk of cancer, especially leukemia and osteosarcoma (bone cancer).

This is potentially a cost-effective alternative to GnRH analogues for the treatment of this condition, as GnRH analogues are very expensive.

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